Lipo-modeling is the process of relocating autologous fat to change the shape, volume, consistency, and profile of tissues, with the aim of reconstructing, rejuvenating, and regenerating body features. There have been several important advancements in Lipo-modeling procedures during the last thirty years. Four clinical steps are important for the success of engraftment: fat harvesting, fat processing, fat re-injection, and pre-conditioning of the recipient site. With the discovery of adipose derived stem cells and de-differentiated cells, fat cells become a major tool of regenerative medicine. This article reviews recent trends in lipo-modeling trying to understand most of the issues in this field.